OS9.5 Evidence that adult glioblastoma adapts to standard therapy though chromatin remodeling

Epigenetics and Chromatin Remodeling in Adult Cardiomyopathy

The manipulation of chromatin structure regulates gene expression and the flow of genetic information. Histone modifications and ATP-dependent chromatin remodeling together with DNA methylation are dynamic processes that modify chromatin architecture and profoundly modulate gene expression. Their coordinated control is key to ensuring proper cell commitment and organ development, as well as ada...

Bioengineering Evidence that Ladybird Beetle Adhesion Fluid Adapts to Changing Surface Chemistry

Complex Mobile Learning that Adapts to Learners' Cognitive Load

Mobile learning is cognitively demanding and frequently the ubiquitous nature of mobile computing means that mobile devices are used in cognitively demanding environments. This paper examines the use of mobile devices from a Learning, Usability and Cognitive Load Theory perspective. It suggests scenarios where these fields interact and presents an experiment which determined that several source...

An architecture for software that adapts to changes in requirements

The goal of the research presented in this paper was to study a new software paradigm ± adaptive software ± in which the structure of an adaptive program is patterned upon the structure of an adaptive controller. Towards this aim, we implemented a domain-speci®c (object/target recognition) program (A Recon®gurable Architecture for Adapting to Changes in the Requirements (RAACR)) that can adapt ...

A tree-based regressor that adapts to intrinsic dimension

We consider the problem of nonparametric regression, consisting of learning an arbitrary mapping f : X → Y from a data set of (x, y) pairs in which the y values are corrupted by noise of mean zero. This statistical task is known to to be subject to a severe curse of dimensionality: if X ⊂ R, and if the only smoothness assumption on f is that it satisfies a Lipschitz condition, it is known that ...